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The timing principle applies across the stack

& Lemaitre, J

In summary, engineered extracellular vesicles, through precise functional design, show significant advantages in improving targeting, optimizing drug loading, and enhancing therapeutic effects, providing new technological pathways for the treatment of intervertebral disc degeneration

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To achieve this, we encourage the scientific community to prioritize transparency in data reporting and to support the publication of all findingsregardless of outcomein order to foster rigorous and reproducible research in the field of natural compound-based AD therapeutics